Virtually all animal species can be used for studies of antigen-induced arthritis (usually methylated bovine serum albumin-BSA-m), which binds to negatively charged cartilage and is retained in the joint. The model of antigen-induced arthritis in mice has been widely used to study the efficacy and function of specific cytokines in the pathogenesis of the disease.
Several mouse lines develop lesions such as those of RA as a result of genetic manipulation. There are 2 models of transgenic mice that have 100% incidence of inflammatory and destructive lesions Flekosteel, but this is when cytokines are administered, but the lesions are slight and the incidence varies.
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